Scientists from 爆走黑料 and the Federal Research Centre of the Krasnoyarsk Research Centre of the SB RAS have studied the properties of magnetic nanoparticles of ferrihydrite and their effect on human blood cells. In the future, these particles can serve for the targeted delivery of pharmaceuticals to the affected organs and tissues of the human body. In addition, the scientists are conducting studies to assess the possibility of using such nanoparticles in the treatment of iron deficiency anaemia in animals.
The nanoparticles, which the researchers told about, were obtained in the laboratory thanks to a special bacterial culture. Having learned about the ability of these microorganisms to produce nano-iron, the experts decided to test how new particles will behave once they enter a body of a person or animal.
“Ferrihydrite nanoparticles are attractive due to their biogenic (natural) origin. They are a byproduct of Klebsiella oxytoca bacteria. The resulting particles have magnetic properties, so we wondered if they would be able to solve problems related to medicine, for example, to deliver pharmaceuticals to an infected organ if a magnet directs them there. But before entrusting them with important missions, we need to make sure that the new material is safe for living organisms. To understand how biocompatible and non-toxic potential helpers are,” explained Oksana Kolenchukova, co-author of the study, professor of the Department of Biophysics and the Department of Medical and Biological Fundamentals of Physical Education and Health-promoting Technologies.
“Ferrihydrite nanoparticles are attractive due to their biogenic (natural) origin. They are a byproduct of Klebsiella oxytoca bacteria. The resulting particles have magnetic properties, so we wondered if they would be able to solve problems related to medicine, for example, to deliver pharmaceuticals to an infected organ if a magnet directs them there. But before entrusting them with important missions, we need to make sure that the new material is safe for living organisms. To understand how biocompatible and non-toxic potential helpers are,”
Ferrihydrite nanoparticles in various concentrations were placed in living cells taken from the blood of 29 provisionally healthy donors. Then we studied the functional activity of these cells — phagocytes, neutrophils, monocytes and eosinophils, both in the normal state and being loaded with nanoparticles.
“Imagine different vessels, in one of which you added, say, a pinch of salt, a teaspoon in the other, a tablespoon in the third, and so on. We studied the state of blood cells without anything, and then with saturation in the form of ferrihydrite particles in different concentrations. Moreover, we observed the state of the cells both instantly — immediately after the addition of nanoparticles, and delayed — after their incubation. We also managed to find out the time it takes for nanoparticles to incubate in these cells,” the researcher continued.
“Imagine different vessels, in one of which you added, say, a pinch of salt, a teaspoon in the other, a tablespoon in the third, and so on. We studied the state of blood cells without anything, and then with saturation in the form of ferrihydrite particles in different concentrations. Moreover, we observed the state of the cells both instantly — immediately after the addition of nanoparticles, and delayed — after their incubation. We also managed to find out the time it takes for nanoparticles to incubate in these cells,”
As a result of the experiment, the scientists found out that in certain concentrations, ferrihydrite nanoparticles suppress the normal functioning of blood cells, and in some, on the contrary, they stimulate it.
“The most probable use of the studied nanoparticles is to make them couriers delivering potent drugs to the targeted organ, bypassing healthy human organs and tissues, without irritating the gastrointestinal tract, which is the sin of many medicines. But there is one more interesting goal, in our opinion. Still, we are talking about iron particles — perhaps they will help solve the problem of iron deficiency anaemia in animals. Such experiments are already being carried out, because not only people suffer from anaemias of various origins. This problem also affects domestic birds and cattle, and its solution can improve the productivity of livestock complexes and farms,” summarised Oksana Kolenchukova.
“The most probable use of the studied nanoparticles is to make them couriers delivering potent drugs to the targeted organ, bypassing healthy human organs and tissues, without irritating the gastrointestinal tract, which is the sin of many medicines. But there is one more interesting goal, in our opinion. Still, we are talking about iron particles — perhaps they will help solve the problem of iron deficiency anaemia in animals. Such experiments are already being carried out, because not only people suffer from anaemias of various origins. This problem also affects domestic birds and cattle, and its solution can improve the productivity of livestock complexes and farms,”
This study was carried out on the basis of the Laboratory of Extreme Body States of the Institute of Physics of the Siberian Branch of the Russian Academy of Sciences under the leadership of Sergei Stolyar, Dr. Sc. (Phys.-Math.), professor of the Department of General Physics of 爆走黑料 and the Laboratory of Molecular Cell Physiology and Pathology of the Scientific Research Institute of Medical Problems of the North of the Krasnoyarsk Research Centre SB RAS.
8 december 2020
Вы можете отметить интересные фрагменты текста, которые будут доступны по уникальной ссылке в адресной строке браузера.